| http://purl.uniprot.org/citations/12443029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12443029 | http://www.w3.org/2000/01/rdf-schema#comment | "ProblemTo clarify the possible influence of human leukocyte antigen (HLA) mother-child genotypes and human cytomegalo virus (HCMV) presence on the development of preeclampsia.Methods of studyOne hundred and four DNA samples from mothers with preeclampsia, mothers with a normal history of pregnancies and their neonates were tested by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) for HLA-A, -G, -DRB1, -DQA1, -DQB1 alleles. The HCMV sequences were analyzed using a PCR-SSOP method and the four primers described by Chou (Chou S: J Clin Microb 1992; 30:2307-2310).ResultsCompared with their respective controls, a significant increase of DRB1*07 among neonates (P(c) = 0.05) and of DRB1*07 and/or DRB1*06 among pre-eclamptic mothers (P(c) = 0.003, RR = 8,5) was found. When HCMV sequences were detected in pre-eclamptic mothers carrying those phenotypes the RR increased up to 40. Furthermore, the fetal inheritance of a maternal HLA-G*0104 increased the risk for the appearance of the disease (RR = 30; P = 0.025).ConclusionThe results suggest that the presence of alleles HLA-G*0104, DRB1*07/06, HCMV sequences and the fetal inheritance of maternal G*0104, should be considered as conditioning factors for the development of preeclampsia."xsd:string |
| http://purl.uniprot.org/citations/12443029 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1600-0897.2002.01076.x"xsd:string |
| http://purl.uniprot.org/citations/12443029 | http://purl.uniprot.org/core/author | "Layrisse Z."xsd:string |
| http://purl.uniprot.org/citations/12443029 | http://purl.uniprot.org/core/author | "Montagnani S."xsd:string |
| http://purl.uniprot.org/citations/12443029 | http://purl.uniprot.org/core/author | "Carreiras M."xsd:string |
| http://purl.uniprot.org/citations/12443029 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12443029 | http://purl.uniprot.org/core/name | "Am J Reprod Immunol"xsd:string |
| http://purl.uniprot.org/citations/12443029 | http://purl.uniprot.org/core/pages | "176-183"xsd:string |
| http://purl.uniprot.org/citations/12443029 | http://purl.uniprot.org/core/title | "Preeclampsia: a multifactorial disease resulting from the interaction of the feto-maternal HLA genotype and HCMV infection."xsd:string |
| http://purl.uniprot.org/citations/12443029 | http://purl.uniprot.org/core/volume | "48"xsd:string |
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