| http://purl.uniprot.org/citations/12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12444549 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of HPV E6 oncoproteins to induce the degradation of PDZ domain-containing MAGUK proteins correlates with their malignant potential. We previously showed that the HPV-6 E6 protein, when provided with the PDZ-binding domain from HPV-18 E6, acquires the ability to bind the Discs Large (Dlg) tumour suppressor and target it for degradation. Based on this finding we have extended this analysis to E6 proteins from a variety of different papillomavirus types. Cloning a PDZ-binding sequence onto the C-terminus of E6 proteins derived from low-risk mucosal, and low and high-risk cutaneous papillomavirus types, enables them to bind Dlg and a second MAGUK family member, MAGI-1. This renders the mucosally-derived low-risk chimaeric HPV E6 proteins capable of targeting Dlg for degradation, but they are unable to induce significant levels of degradation of MAGI-1. In contrast, none of the E6 proteins derived from cutaneous papillomavirus types induce significant degradation of either MAGI-1 or Dlg when provided with a PDZ-binding domain. These results demonstrate significant differences, both between mucosal and cutaneous HPV E6 proteins and in the pathways required for Dlg and MAGI-1 degradation."xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206026"xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://purl.uniprot.org/core/author | "Thomas M."xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://purl.uniprot.org/core/author | "Banks L."xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://purl.uniprot.org/core/author | "Pim D."xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12444549 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://purl.uniprot.org/core/pages | "8140-8148"xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://purl.uniprot.org/core/title | "Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins."xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12444549 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12444549 |
| http://purl.uniprot.org/citations/12444549 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12444549 |
| http://purl.uniprot.org/uniprot/#_P03126-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_P03127-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_Q12959-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_P06428-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_P06462-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_P06463-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_P06931-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_P04019-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_P17386-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/#_Q96QZ7-mappedCitation-12444549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/P17386 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12444549 |
| http://purl.uniprot.org/uniprot/Q96QZ7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12444549 |