| http://purl.uniprot.org/citations/12446569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12446569 | http://www.w3.org/2000/01/rdf-schema#comment | "We have demonstrated previously that Xenopus Aurora-A is degraded at late mitosis by the APC/Fizzy-Related in a D-Box-dependent manner. Here we demonstrate that, although Aurora-B possesses the same D-Box as Aurora-A, Aurora-B is not degraded by this ubiquitin ligase. We have constructed a chimera Aurora-A/B with the N-terminus of Aurora-A and the C-terminus of Aurora-B and we have examined its degradation by APC/Fizzy-Related. We demonstrate that the N-terminus of Aurora-A confers degradation capacity on the C-terminus of Aurora-B and that this feature is blocked by mutation of the conserved D-Box sequence. We characterize the minimal degradation signal at the N-terminus of Aurora-A and demonstrate that its deletion blocks the degradation of this protein by APC/Fizzy-Related. Thus, we conclude that two different degradation signals are required for proteolysis of Aurora-A. The first one, which we designated D-Box-activating domain, within the N-terminal domain of Aurora-A confers the functionality to the second, a silent D-Box, present within the C-terminus of the kinase."xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.org/dc/terms/identifier | "doi:10.1093/embo-reports/kvf241"xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/author | "Labbe J.C."xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/author | "Castro A."xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/author | "Lorca T."xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/author | "Vigneron S."xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/author | "Prigent C."xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/author | "Bernis C."xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/pages | "1209-1214"xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/title | "The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A."xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/12446569 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12446569 |
| http://purl.uniprot.org/citations/12446569 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12446569 |
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| http://purl.uniprot.org/uniprot/#_Q12834-mappedCitation-12446569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12446569 |
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| http://purl.uniprot.org/uniprot/#_O14965-mappedCitation-12446569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12446569 |
| http://purl.uniprot.org/uniprot/#_O95997-mappedCitation-12446569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12446569 |
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| http://purl.uniprot.org/uniprot/#_P53350-mappedCitation-12446569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12446569 |