| http://purl.uniprot.org/citations/12446585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12446585 | http://www.w3.org/2000/01/rdf-schema#comment | "The progesterone receptor (PR) gene is activated by estrogen in MCF-7 human breast cancer cells. Although the human PR gene does not contain an estrogen response element (ERE), we have identified a putative activating protein-1 (AP-1) site at +90 in the PR gene that was hypersensitive to deoxyribonuclease I cleavage in genomic Southern analysis, bound purified Fos and Jun, formed a complex with Fos/Jun heterodimers present in MCF-7 nuclear extracts in gel mobility shift assays, and functioned as an estrogen-responsive enhancer in transient cotransfection assays. When the +90 AP-1 site was mutated in the context of the PR gene, estrogen responsiveness was significantly decreased. Purified estrogen receptor (ER) enhanced binding of Fos and Jun to the +90 AP-1 site and bound to an adjacent imperfect ERE half-site. Mutating this ERE half-site diminished the binding of ER, Fos, and Jun and decreased transcription. Chromatin immunoprecipitation assays demonstrated that the ER, Fos, and Jun were present at the +90 AP-1 site in the endogenous PR gene only after treatment of MCF-7 cells with estrogen. These studies suggest that the cooperative interaction of the ER with Fos and Jun proteins helps confer estrogen responsiveness to the endogenous PR gene."xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2002-220369"xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/author | "Ziegler Y.S."xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/author | "Loven M.A."xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/author | "Nardulli A.M."xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/author | "Petz L.N."xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/pages | "4583-4591"xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/title | "Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/12446585 | http://purl.uniprot.org/core/volume | "143"xsd:string |
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