| http://purl.uniprot.org/citations/12446687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12446687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12446687 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt growth factors control numerous cell fate decisions in development by altering specific gene expression patterns through the activity of heterodimeric transcriptional activators. These consist of beta-catenin and one of the four members of the T-cell factor (TCF) family of DNA-binding proteins. How can the Wnt/beta-catenin pathway control various sets of target genes in distinct cellular settings with such a limited number of nuclear effectors? Here we asked whether different TCF proteins could perform specific, nonredundant functions at natural beta-catenin/TCF-regulated promoters. We found that TCF4E but not LEF1 supported beta-catenin-dependent activation of the Cdx1 promoter, whereas LEF1 specifically activated the Siamois promoter. Deletion of a C-terminal domain of TCF4E prevented Cdx1 promoter induction. A chimeric protein consisting of LEF1 and the C terminus of TCF4E was fully functional. Therefore, the TCF4E C terminus harbors a promoter-specific transactivation domain. This domain influences the DNA binding properties of TCF4 and additionally mediates an interaction with the transcriptional coactivator p300. Apparently, the C terminus of TCF4E cooperates with beta-catenin and p300 to form a specialized transcription factor complex that specifically supports the activation of the Cdx1 promoter."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210081200"xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210081200"xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/author | "Hecht A."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/author | "Hecht A."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/author | "Stemmler M.P."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/author | "Stemmler M.P."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/pages | "3776-3785"xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/pages | "3776-3785"xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/title | "Identification of a promoter-specific transcriptional activation domain at the C-terminus of the Wnt effector protein T-cell factor 4."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/title | "Identification of a promoter-specific transcriptional activation domain at the C-terminus of the Wnt effector protein T-cell factor 4."xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12446687 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12446687 |
| http://purl.uniprot.org/citations/12446687 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12446687 |
| http://purl.uniprot.org/citations/12446687 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12446687 |
| http://purl.uniprot.org/citations/12446687 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12446687 |
| http://purl.uniprot.org/uniprot/Q09472 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12446687 |
| http://purl.uniprot.org/uniprot/P27782 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12446687 |