| http://purl.uniprot.org/citations/12446773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12446773 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have suggested that the early-B-cell-specific mb-1(Igalpha) promoter is regulated by EBF and Pax-5. Here, we used in vivo footprinting assays to detect occupation of binding sites in endogenous mb-1 promoters at various stages of B-cell differentiation. In addition to EBF and Pax-5 binding sites, we detected occupancy of a consensus binding site for E2A proteins (E box) in pre-B cells. EBF and E box sites are crucial for promoter function in transfected pre-B cells, and EBF and E2A proteins synergistically activated the promoter in transfected HeLa cells. Other data suggest that EBF and E box sites are less important for promoter function at later stages of differentiation, whereas binding sites for Pax-5 (and its Ets ternary complex partners) are required for promoter function in all mb-1-expressing cells. Using DNA microarrays, we found that expression of endogenous mb-1 transcripts correlates most closely with EBF expression and negatively with Id1, an inhibitor of E2A protein function, further linking regulation of the mb-1 gene with EBF and E2A. Together, our studies demonstrate the complexity of factors regulating tissue-specific transcription and support the concept that EBF, E2A, and Pax-5 cooperate to activate target genes in early B-cell development."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.24.8539-8551.2002"xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Akerblad P."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Sigvardsson M."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Doyle M."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Hagman J."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Clark D.R."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Fitzsimmons D."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Bilke S."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Breslin T."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/author | "Yeamans C."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/pages | "8539-8551"xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/title | "Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter."xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12446773 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12446773 |
| http://purl.uniprot.org/citations/12446773 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12446773 |
| http://purl.uniprot.org/uniprot/Q07802#attribution-7109B1ABAEF5194CDDF8A09E742126A1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12446773 |
| http://purl.uniprot.org/uniprot/P15806#attribution-7109B1ABAEF5194CDDF8A09E742126A1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12446773 |
| http://purl.uniprot.org/uniprot/#_Q07802-mappedCitation-12446773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12446773 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J011-mappedCitation-12446773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12446773 |