| http://purl.uniprot.org/citations/12446777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12446777 | http://www.w3.org/2000/01/rdf-schema#comment | "Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases (PI3Ks). To assess the role of the delta isoform of the p110 catalytic subunit of PI3Ks, we derived enzyme-deficient mice. The mice are viable but have decreased numbers of mature B cells, a block in pro-B-cell differentiation, and a B1 B-cell deficiency. Both immunoglobulin M receptor-induced Ca(2+) flux and proliferation in response to B-cell mitogens are attenuated. Immunoglobulin levels are decreased substantially. The ability to respond to T-cell-independent antigens is markedly reduced, and the ability to respond to T-cell-dependent antigens is completely eliminated. Germinal center formation in the spleen in response to antigen stimulation is disrupted. These results define a nonredundant signaling pathway(s) utilizing the delta isoform of p110 PI3K for the development and function of B cells."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.24.8580-8591.2002"xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/author | "Ihle J.N."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/author | "Carpino N."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/author | "Chao J.R."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/author | "Piekorz R."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/author | "Carpino N.'"xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/author | "Jou S.T."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/pages | "8580-8591"xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/title | "Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex."xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12446777 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12446777 |
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