| http://purl.uniprot.org/citations/12447390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12447390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12447390 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in signalling the presence of DNA damage. Here, we show that mice lacking either H2AX or 53BP1, but not Chk2, manifest a G2-M checkpoint defect close to that observed in ATM(-/-) cells after exposure to low, but not high, doses of IR. Moreover, H2AX regulates the ability of 53BP1 to efficiently accumulate into IR-induced foci. We propose that at threshold levels of DNA damage, H2AX-mediated concentration of 53BP1 at double-strand breaks is essential for the amplification of signals that might otherwise be insufficient to prevent entry of damaged cells into mitosis."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb884"xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb884"xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Naka K."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Naka K."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Xia Z."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Xia Z."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Carpenter P.B."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Carpenter P.B."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Bonner W.M."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Bonner W.M."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Chen H.-T."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Chen H.-T."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Camerini-Otero R.D."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Camerini-Otero R.D."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Motoyama N."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Motoyama N."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Fernandez-Capetillo O."xsd:string |
| http://purl.uniprot.org/citations/12447390 | http://purl.uniprot.org/core/author | "Fernandez-Capetillo O."xsd:string |