| http://purl.uniprot.org/citations/12447393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12447393 | http://www.w3.org/2000/01/rdf-schema#comment | "ARF6-regulated endocytosis of E-cadherin is essential during the disassembly of adherens junctions in epithelial cells. Here, we show that activation of ARF6 promotes clathrin-dependent internalization of E-cadherin and caveolae at the basolateral cell surface. Furthermore, we demonstrate that ARF6-GTP, a constitutively activate form of ARF6, interacts with and recruits Nm23-H1, a nucleoside diphosphate (NDP) kinase that provides a source of GTP for dynamin-dependent fission of coated vesicles during endocytosis. Finally, we show that ARF6-mediated recruitment of Nm-23-H1 to cell junctions is accompanied by a decrease in the cellular levels of Rac1-GTP, consistent with previous findings that Nm23-H1 down-regulates activation of Rac1. These studies provide a molecular basis for ARF6 function in polarized epithelia during adherens junction disassembly."xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb881"xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/author | "D'Souza-Schorey C."xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/author | "Schweitzer J.K."xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/author | "Boshans R.L."xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/author | "Palacios F."xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/pages | "929-936"xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/title | "ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly."xsd:string |
| http://purl.uniprot.org/citations/12447393 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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