| http://purl.uniprot.org/citations/12450794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12450794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12450794 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA tumor virus oncoproteins bind and inactivate Rb by interfering with the Rb/HDAC1 interaction. Che-1 is a recently identified human Rb binding protein that inhibits the Rb growth suppressing function. Here we show that Che-1 contacts the Rb pocket region and competes with HDAC1 for Rb binding site, removing HDAC1 from the Rb/E2F complex in vitro and from the E2F target promoters in vivo. Che-1 overexpression activates DNA synthesis in quiescent NIH-3T3 cells through HDAC1 displacement. Consistently, Che-1-specific RNA interference affects E2F activity and cell proliferation in human fibroblasts but not in the pocket protein-defective 293 cells. These findings indicate the existence of a pathway of Rb regulation supporting Che-1 as the cellular counterpart of DNA tumor virus oncoproteins."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1535-6108(02)00182-4"xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1535-6108(02)00182-4"xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Barbato C."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Barbato C."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Benassi B."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Benassi B."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Chersi A."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Chersi A."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Corbi N."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Corbi N."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "De Angelis R."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "De Angelis R."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Di Padova M."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Di Padova M."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Floridi A."xsd:string |
| http://purl.uniprot.org/citations/12450794 | http://purl.uniprot.org/core/author | "Floridi A."xsd:string |