| http://purl.uniprot.org/citations/12453415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12453415 | http://www.w3.org/2000/01/rdf-schema#comment | "The calcineurin-regulated transcription factor, nuclear factor of activated T cells (NFAT), controls many aspects of T cell function. Here, we demonstrate that the calcineurin/NFAT pathway negatively regulates the expression of cyclin-dependent kinase 4 (CDK4). A canonical NFAT binding site was identified and found to be sensitive to calcium signals, FK506/CsA, and histone deacetylase activity and to not require AP-1. Ectopic expression of NFATc2 inhibited the basal activity of the human CDK4 promoter. Additionally, both calcineurin Aalpha(-/-) and NFATc2(-/-) mice had elevated protein levels of CDK4, confirming a negative regulatory role for the calcineurin/NFAT pathway. This pathway may thus regulate the expression of CDK4 at the transcriptional level and control how cells re-enter a resting, nonproliferative state."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00701-3"xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "Du J."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "Fosmire S."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "Burakoff S.J."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "Frazer-Abel A.A."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "Baksh S."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "Fisher D.E."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "Widlund H.R."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/author | "Modiano J.F."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/pages | "1071-1081"xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/title | "NFATc2-mediated repression of cyclin-dependent kinase 4 expression."xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12453415 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12453415 |
| http://purl.uniprot.org/citations/12453415 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12453415 |
| http://purl.uniprot.org/uniprot/Q60591#attribution-BBAD5BE9E7D096773E7840D5B7911AB5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12453415 |
| http://purl.uniprot.org/uniprot/#_E9Q9E4-mappedCitation-12453415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12453415 |
| http://purl.uniprot.org/uniprot/#_D3YWB0-mappedCitation-12453415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12453415 |
| http://purl.uniprot.org/uniprot/#_E9PZX7-mappedCitation-12453415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12453415 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-12453415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12453415 |
| http://purl.uniprot.org/uniprot/#_B5B2P6-mappedCitation-12453415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12453415 |