| http://purl.uniprot.org/citations/12455993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12455993 | http://www.w3.org/2000/01/rdf-schema#comment | "The Saccharomyces cerevisiae mRNA capping enzyme consists of two subunits: an RNA 5'-triphosphatase (RTPase) and GTP::mRNA guanylyltransferase (GTase). The GTase subunit (Ceg1) binds to the phosphorylated carboxyl-terminal domain of the largest subunit (CTD-P) of RNA polymerase II (pol II), coupling capping with transcription. Ceg1 bound to the CTD-P is inactive unless allosterically activated by interaction with the RTPase subunit (Cet1). For purposes of comparison, we characterize here the related GTases and RTPases from the yeasts Schizosaccharomyces pombe and Candida albicans. Surprisingly, the S. pombe capping enzyme subunits do not interact with each other. Both can independently interact with CTD-P of pol II, and the GTase is not repressed by CTD-P binding. The S. pombe RTPase gene (pct1+) is essential for viability. Pct1 can replace the S. cerevisiae RTPase when GTase activity is supplied by the S. pombe or mouse enzymes but not by the S. cerevisiae GTase. The C. albicans capping enzyme subunits do interact with each other. However, this interaction is not essential in vivo. Our results reveal an unexpected diversity among the fungal capping machineries."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.org/dc/terms/identifier | "doi:10.1128/ec.1.3.448-457.2002"xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Takagi T."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Janoo R.T."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Buratowski S."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Cho E.J."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Takase Y."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Hoffman C.S."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Keogh M.C."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Fresco-Cohen L.D."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Polodny V."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/author | "Woo S.A."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/name | "Eukaryot Cell"xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/pages | "448-457"xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/title | "Divergent subunit interactions among fungal mRNA 5'-capping machineries."xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/12455993 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12455993 |
| http://purl.uniprot.org/citations/12455993 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12455993 |
| http://purl.uniprot.org/uniprot/Q9P6Q6#attribution-7FB985AAF35BA8F2267DBDB4A5DEA7BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12455993 |
| http://purl.uniprot.org/uniprot/Q9P6Q6#attribution-A465DD786DDD44892FE32BF09C8849AB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12455993 |
| http://purl.uniprot.org/uniprot/P40997#attribution-7FB985AAF35BA8F2267DBDB4A5DEA7BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12455993 |
| http://purl.uniprot.org/uniprot/P40997#attribution-A465DD786DDD44892FE32BF09C8849AB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12455993 |
| http://purl.uniprot.org/uniprot/#_O13297-mappedCitation-12455993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12455993 |