| http://purl.uniprot.org/citations/12458207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12458207 | http://www.w3.org/2000/01/rdf-schema#comment | "Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates c-jun N-terminal kinase (JNK) and can induce cell death in neurons. By contrast, the activation of phosphatidylinositol 3-kinase and AKT/protein kinase B (PKB) acts to suppress neuronal apoptosis. Here, we report a functional interaction between MLK3 and AKT1/PKBalpha. Endogenous MLK3 and AKT1 interact in HepG2 cells, and this interaction is regulated by insulin. The interaction domain maps to the C-terminal half of MLK3 (amino acids 511-847), and this region also contains a putative AKT phosphorylation consensus sequence. Endogenous JNK, MKK7, and MLK3 kinase activities in HepG2 cells are significantly attenuated by insulin treatment, whereas the phosphatidylinositol 3-kinase inhibitors LY294002 and wortmannin reversed the effect. Finally, MLK3-mediated JNK activation is inhibited by AKT1. AKT phosphorylates MLK3 on serine 674 both in vitro and in vivo. Furthermore, the expression of activated AKT1 inhibits MLK3-mediated cell death in a manner dependent on serine 674 phosphorylation. Thus, these data provide the first direct link between MLK3-mediated cell death and its regulation by a cell survival signaling protein, AKT1."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m211598200"xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/author | "Kundu C.N."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/author | "Sharma C."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/author | "Rana A."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/author | "Barthwal M.K."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/author | "Sathyanarayana P."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/author | "Rana B."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/author | "Pradeep A."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/pages | "3897-3902"xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/title | "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival."xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12458207 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12458207 |
| http://purl.uniprot.org/citations/12458207 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12458207 |
| http://purl.uniprot.org/uniprot/#_A0A139ZZA2-mappedCitation-12458207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12458207 |
| http://purl.uniprot.org/uniprot/#_B2RDI6-mappedCitation-12458207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12458207 |
| http://purl.uniprot.org/uniprot/#_B3KQY4-mappedCitation-12458207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12458207 |
| http://purl.uniprot.org/uniprot/#_B3KQ31-mappedCitation-12458207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12458207 |
| http://purl.uniprot.org/uniprot/#_Q16584-mappedCitation-12458207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12458207 |
| http://purl.uniprot.org/uniprot/#_Q14289-mappedCitation-12458207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12458207 |
| http://purl.uniprot.org/uniprot/#_Q6ZRA8-mappedCitation-12458207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12458207 |