| http://purl.uniprot.org/citations/12459033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12459033 | http://www.w3.org/2000/01/rdf-schema#comment | "Transferrin (Tf) is an iron transport protein expressed in MCF-7 human breast cancer cells. In nuclear run-on assays, 17beta-estradiol (E2) increased the rate of Tf gene expression approximately 3-fold within 1 h after treatment and reporter gene activity was also induced in MCF-7 cells transfected with a construct containing a -3600 to +39 Tf gene promoter insert. Deletion and mutation analysis identified an E2-responsive promoter region between -811 and -762, which was GC-rich (80%) and contained two nonconsensus estrogen response elements (EREs). E2-responsiveness of this region was associated with a GGACA(N)(3)TGGCC motif (-803 to -791) which bound human estrogen receptor alpha (hERalpha) in gel mobility shift assays. In Drosophila Schneider SL-2 cells, the -811 to -752 was E2-responsive after cotransfection with hERalpha expression plasmid plus E2, whereas Sp1 protein did not induce transactivation. These studies confirm that E2 induces Tf gene expression through a nonconsensus distal ERE."xsd:string |
| http://purl.uniprot.org/citations/12459033 | http://purl.org/dc/terms/identifier | "doi:10.1677/jme.0.0290305"xsd:string |
| http://purl.uniprot.org/citations/12459033 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/12459033 | http://purl.uniprot.org/core/author | "Safe S."xsd:string |
| http://purl.uniprot.org/citations/12459033 | http://purl.uniprot.org/core/author | "Vyhlidal C."xsd:string |
| http://purl.uniprot.org/citations/12459033 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12459033 | http://purl.uniprot.org/core/name | "J Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/12459033 | http://purl.uniprot.org/core/pages | "305-317"xsd:string |
| http://purl.uniprot.org/citations/12459033 | http://purl.uniprot.org/core/title | "Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/12459033 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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