| http://purl.uniprot.org/citations/12464391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12464391 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study demonstrated that endotheline-1 (ET-1) stimulated a biphasic (transient and sustained) increase in [Ca(2+)](i) and signaling was blocked by BQ123 and inhibited by BQ788. RT-PCR analysis revealed that ET(A) was expressed more than ET(B) mRNA-suggesting that ET(A) is the major receptor. Simply reintroducing Ca(2+) in the buffer stimulated a sustained increase in [Ca(2+)](i) and the effect was inhibited by U73122, thapsigargin (TG), miconazole and SKF96365. When measured in Ca(2+)-free buffer, the ET-1-stimulated Ca(2+) transient decreased by 73% and the reintroduction of Ca(2+) induced a large sustained increase in [Ca(2+)](i). These effects were not affected by nifedipine, but were inhibited by miconazole and SKF96365-indicating that the sustained increase in [Ca(2+)](i) mediated by ET-1 was mostly due to capacitative Ca(2+) entry (CCE). The ET-1-induced CCE was inhibited by phorbol ester (PMA) but was enhanced by GF109203X; it was also enhanced by 8-bromo-cyclic AMP (8-Br-cAMP) but was inhibited by H89. Thus, protein kinase C (PKC) negatively regulated and cAMP-dependent protein kinase (PKA) positively regulated the ET-1-mediated CCE in these cells."xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0898-6568(02)00079-7"xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/author | "Wang C.M."xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/author | "Lo J.C."xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/author | "Lin H.J."xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/author | "Sun S.H."xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/author | "Hung A.C."xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/author | "Ju Y.J."xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/pages | "197-207"xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/title | "Endothelin-1 stimulated capacitative Ca2+ entry through ET(A) receptors of a rat brain-derived type-1 astrocyte cell line, IA-1g1."xsd:string |
| http://purl.uniprot.org/citations/12464391 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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