| http://purl.uniprot.org/citations/12466202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12466202 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ras signalling pathway has major roles in normal cell function and oncogenesis. C3G is a guanine nucleotide exchange factor for members of the Ras family of GTPases. We generated a mouse strain with a hypomorphic C3G allele. C3G(gt/gt) mutant embryos died of vascular defects around E11.5 due to haemorrhage and vascular integrity defects. Vascular supporting cells did not develop appropriately. C3G-deficient fibroblasts responded to PDGF-BB abnormally, exhibited cell adhesion defects and lacked paxillin and integrin-beta1-positive cell adhesions. In contrast, integrin-beta3-positive cell adhesions formed normally. These results show that C3G is required for (1) vascular myogenesis, (2) the formation of paxillin- and integrin beta1-positive, but not integrin beta3-positive, cell adhesions and (3) normal response to PDGF, necessary for vascular myogenesis."xsd:string |
| http://purl.uniprot.org/citations/12466202 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.00217"xsd:string |
| http://purl.uniprot.org/citations/12466202 | http://purl.uniprot.org/core/author | "Thomas T."xsd:string |
| http://purl.uniprot.org/citations/12466202 | http://purl.uniprot.org/core/author | "Gruss P."xsd:string |
| http://purl.uniprot.org/citations/12466202 | http://purl.uniprot.org/core/author | "Voss A.K."xsd:string |
| http://purl.uniprot.org/citations/12466202 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12466202 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/12466202 | http://purl.uniprot.org/core/pages | "355-367"xsd:string |
| http://purl.uniprot.org/citations/12466202 | http://purl.uniprot.org/core/title | "The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation."xsd:string |
| http://purl.uniprot.org/citations/12466202 | http://purl.uniprot.org/core/volume | "130"xsd:string |
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