http://purl.uniprot.org/citations/12466206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12466206 | http://www.w3.org/2000/01/rdf-schema#comment | "Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion within the Ebf2 (O/E3) gene. In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading to secondary hypogonadism. In addition, Ebf2(-/-) peripheral nerves feature defective axon sorting, hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity. Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.00215"xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Broccoli V."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Wurst W."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Previtali S."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Quattrini A."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Consalez G.G."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Croci L."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Corradi A."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Maggi R."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Amadio S."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/author | "Zecchini S."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/name | "Development"xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/pages | "401-410"xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/title | "Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice."xsd:string |
http://purl.uniprot.org/citations/12466206 | http://purl.uniprot.org/core/volume | "130"xsd:string |
http://purl.uniprot.org/citations/12466206 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12466206 |
http://purl.uniprot.org/citations/12466206 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12466206 |
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http://purl.uniprot.org/uniprot/#_A0A286YDB0-mappedCitation-12466206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12466206 |
http://purl.uniprot.org/uniprot/#_A0A087WST5-mappedCitation-12466206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12466206 |