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http://purl.uniprot.org/citations/12467609http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12467609http://www.w3.org/2000/01/rdf-schema#comment"The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors."xsd:string
http://purl.uniprot.org/citations/12467609http://purl.org/dc/terms/identifier"doi:10.1016/s0960-894x(02)00852-1"xsd:string
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/author"Sato A."xsd:string
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/author"Kinoshita T."xsd:string
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/author"Nakanishi I."xsd:string
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/author"Tada T."xsd:string
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/name"Bioorg Med Chem Lett"xsd:string
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/pages"21-24"xsd:string
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/title"True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor."xsd:string
http://purl.uniprot.org/citations/12467609http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/12467609http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12467609
http://purl.uniprot.org/citations/12467609http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12467609
http://purl.uniprot.org/uniprot/#_P00772-mappedCitation-12467609http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12467609
http://purl.uniprot.org/uniprot/P00772http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/12467609