| http://purl.uniprot.org/citations/12468440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12468440 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate repair mechanisms in bleomycin-induced pulmonary fibrosis, we used mice deficient in gamma-glutamyl transpeptidase (GGT-/-), a key enzyme in glutathione (GSH) and cysteine metabolism. Seventy-two hours after bleomycin (0.03 U/g), GGT-/-mice displayed a different inflammatory response to wild-type mice as judged by a near absence of neutrophils in lung tissue and bronchoalveolar lavage and a less pronounced rise in matrix metalloproteinase-9. Inflammation in GGT-/-mice consisted mainly of lymphocytes and macrophages. At 1 month, lungs from bleomycin-treated GGT-/-mice exhibited minimal areas of fibrosis compared with wild-type mice(light microscopy fibrosis index: 510 +/- 756 versus 1975 +/-817, p < 0.01). Lung collagen content revealed a significant increase in bleomycin-treated wild-type (15.1 +/- 3.8 versus 8.5 +/-0.7 microg hydroxy(OH)-proline/mg dry weight, p < 0.01) but not in GGT-/-(10.4 +/- 1.7 versus 8.8 +/- 0.8). Control lungs from GGT-/-showed a significant reduction of cysteine (0.03 +/- 0.005 versus 0.055 +/-0.001, p < 0.02) and GSH levels (1.24 +/- 0.055 versus 1.79 +/-0.065, p < 0.002). These values decreased after 72 hours of bleomycin in both GGT-/- and wild-type but reached their respective control values after 1 month. Supplementation with N-acetyl cysteine partially ameliorated the effects of GGT deficiency. These findings suggest that increased neutrophils and matrix metalloproteinase-9 during the early inflammatory response and adequate thiol reserves are key elements in the fibrotic response after bleomycin-induced pulmonary injury."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.org/dc/terms/identifier | "doi:10.1164/rccm.200209-1007oc"xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Ramirez R."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Selman M."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Lieberman M.W."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Barrios R."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Pardo A."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Kala S.V."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Ruiz V."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Arreola J.L."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Cisneros-Lira J."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/author | "Gaxiola M."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/name | "Am J Respir Crit Care Med"xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/pages | "925-932"xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/title | "Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/12468440 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12468440 |
| http://purl.uniprot.org/citations/12468440 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12468440 |
| http://purl.uniprot.org/uniprot/Q60928#attribution-E9413DA7E025068C9B089E13DFB92639 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12468440 |
| http://purl.uniprot.org/uniprot/#_D3YVX1-mappedCitation-12468440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12468440 |
| http://purl.uniprot.org/uniprot/#_D3YVY4-mappedCitation-12468440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12468440 |
| http://purl.uniprot.org/uniprot/#_D3YY79-mappedCitation-12468440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12468440 |
| http://purl.uniprot.org/uniprot/#_D3YYH6-mappedCitation-12468440 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12468440 |