| http://purl.uniprot.org/citations/12470648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12470648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12470648 | http://www.w3.org/2000/01/rdf-schema#comment | "Axl receptor tyrosine kinase is implicated in several malignancies and is the receptor for the vitamin K-dependent growth factor Gas6. From a yeast two-hybrid screen of protein-protein interactions with the Axl cytoplasmic domain, we detected a previously uncharacterised SH2 domain-containing protein. We cloned two novel splice variants of this protein that give rise to 1409- and 1419-amino acid proteins, differing only in their N-terminal residues and yielding a 150-kDa protein product by in vitro translation. The Axl-interacting C-terminus contains a tandem SH2 and PTB domain combination homologous to the focal adhesion protein tensin. We detected interaction of Axl with both domains in mammalian cells by co-immunoprecipitation and two-hybrid analyses. In addition, the protein possesses an N-terminal putative phorbol ester-binding C1 domain as well as a central tyrosine phosphatase motif. Thus, we have named the protein C1 domain-containing phosphatase and TENsin homologue (C1-TEN). Northern blot analysis of C1-TEN in human tissues revealed highest expression in heart, kidney, and liver. In summary, we have identified a novel multi-domain intracellular protein that interacts with Axl and which may furthermore be involved in other signal transduction pathways."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02718-3"xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02718-3"xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/author | "Karlsson R."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/author | "Karlsson R."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/author | "Dahlbaeck B."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/author | "Dahlbaeck B."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/author | "Hafizi S."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/author | "Hafizi S."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/author | "Alindri F."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/author | "Alindri F."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/pages | "793-800"xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/pages | "793-800"xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/title | "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/title | "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/volume | "299"xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://purl.uniprot.org/core/volume | "299"xsd:string |
| http://purl.uniprot.org/citations/12470648 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12470648 |
| http://purl.uniprot.org/citations/12470648 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12470648 |