| http://purl.uniprot.org/citations/12471095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12471095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12471095 | http://www.w3.org/2000/01/rdf-schema#comment | "MyD88 is a Toll/IL-1 receptor (TIR) domain-containing adapter common to signaling pathways via Toll-like receptor (TLR) family. However, accumulating evidence demonstrates the existence of a MyD88-independent pathway, which may explain unique biological responses of individual TLRs, particularly TLR3 and TLR4. TIR domain-containing adapter protein (TIRAP)/MyD88 adapter-like, a second adapter harboring the TIR domain, is essential for MyD88-dependent TLR2 and TLR4 signaling pathways, but not for MyD88-independent pathways. Here, we identified a novel TIR domain-containing molecule, named TIR domain-containing adapter inducing IFN-beta (TRIF). As is the case in MyD88 and TIRAP, overexpression of TRIF activated the NF-kappaB-dependent promoter. A dominant-negative form of TRIF inhibited TLR2-, TLR4-, and TLR7-dependent NF-kappaB activation. Furthermore, TRIF, but neither MyD88 nor TIRAP, activated the IFN-beta promoter. Dominant-negative TRIF inhibited TLR3-dependent activation of both the NF-kappaB-dependent and IFN-beta promoters. TRIF associated with TLR3 and IFN regulatory factor 3. These findings suggest that TRIF is involved in the TLR signaling, particularly in the MyD88-independent pathway."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.12.6668"xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.12.6668"xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Mori K."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Mori K."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Hoshino K."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Hoshino K."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/pages | "6668-6672"xsd:string |
| http://purl.uniprot.org/citations/12471095 | http://purl.uniprot.org/core/pages | "6668-6672"xsd:string |