| http://purl.uniprot.org/citations/12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12471105 | http://www.w3.org/2000/01/rdf-schema#comment | "Phospholipase Cgamma2 (PLCgamma2) plays a critical role in the functions of the B cell receptor in B cells and of the FcRgamma chain-containing collagen receptor in platelets. Here we report that PLCgamma2 is also expressed in mast cells and monocytes/macrophages and is activated by cross-linking of Fc(epsilon)R and Fc(gamma)R. Although PLCgamma2-deficient mice have normal development and numbers of mast cells and monocytes/macrophages, we demonstrate that PLCgamma2 is essential for specific functions of Fc(epsilon)R and Fc(gamma)R. While PLCgamma2-deficient mast cells have normal mitogen-activated protein kinase activation and cytokine production at mRNA levels, the mutant cells have impaired Fc(epsilon)R-mediated Ca(2+) flux and inositol 1,4,5-trisphosphate production, degranulation, and cytokine secretion. As a physiological consequence of the effect of PLCgamma2 deficiency, the mutant mice are resistant to IgE-mediated cutaneous inflammatory skin reaction. Macrophages from PLCgamma2-deficient mice have no detectable Fc(gamma)R-mediated Ca(2+) flux; however, the mutant cells have normal Fc(gamma)R-mediated phagocytosis. Moreover, PLCgamma2 plays a nonredundant role in Fc(gamma)R-mediated inflammatory skin reaction."xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.12.6743"xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/author | "Wen R."xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/author | "Hoffmeyer A."xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/author | "Jou S.T."xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/pages | "6743-6752"xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/title | "Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R."xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/12471105 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12471105 |
| http://purl.uniprot.org/citations/12471105 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12471105 |
| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_A2A4A6-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_G3UXP4-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_G3V016-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_F6SLL0-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_Q13094-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_Q62077-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_O75791-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_P16885-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |
| http://purl.uniprot.org/uniprot/#_O43561-mappedCitation-12471105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12471105 |