| http://purl.uniprot.org/citations/12471263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12471263 | http://www.w3.org/2000/01/rdf-schema#comment | "The Frizzled-2 receptor (Rfz2) from rat binds Wnt proteins and can signal by activating calcium release from intracellular stores. We show that wild-type Rfz2 and a chimeric receptor consisting of the extracellular and transmembrane portions of the beta2-adrenergic receptor with cytoplasmic domains of Rfz2 also signaled through modulation of cyclic guanosine 3',5'-monophosphate (cGMP). Activation of either receptor led to a decline in the intracellular concentration of cGMP, a process that was inhibited in cells treated with pertussis toxin, reduced by suppression of the expression of the heterotrimeric GTP-binding protein (G protein) transducin, and suppressed through inhibition of cGMP-specific phosphodiesterase (PDE) activity. Moreover, PDE inhibitors blocked Rfz2-induced calcium transients in zebrafish embryos. Thus, Frizzled-2 appears to couple to PDEs and calcium transients through G proteins."xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1073776"xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/author | "Wang H.Y."xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/author | "Malbon C.C."xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/author | "Slusarski D.C."xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/author | "Ahumada A."xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/pages | "2006-2010"xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/title | "Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP."xsd:string |
| http://purl.uniprot.org/citations/12471263 | http://purl.uniprot.org/core/volume | "298"xsd:string |
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| http://purl.uniprot.org/citations/12471263 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12471263 |
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