| http://purl.uniprot.org/citations/12475942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12475942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12475942 | http://www.w3.org/2000/01/rdf-schema#comment | "Although protein kinase A (PKA) activation is known to increase ciliary beat frequency in humans the molecular mechanisms involved are unknown. We demonstrate that PKA is associated with ciliary axonemes where it specifically phosphorylates a 23-kDa protein. Because PKA is often localized to subcellular compartments in proximity to its substrate(s) via interactions with A-kinase-anchoring proteins (AKAPs), we investigated whether an AKAP was also associated with ciliary axonemes. This study has identified a novel 28 kDa AKAP (AKAP28)that is highly enriched in airway axonemes. The mRNA for AKAP28 is up-regulated as primary airway cells differentiate and is specifically expressed in tissues containing cilia and/or flagella. Additionally, both Western blot and immunostaining data show that AKAP28 is enriched in airway cilia. These data demonstrate that we have identified the first human axonemal AKAP, a protein that likely plays a role in the signaling necessary for efficient modulation of ciliary beat frequency."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e02-07-0391"xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e02-07-0391"xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/author | "Byrd S.K."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/author | "Byrd S.K."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/author | "Kultgen P.L."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/author | "Kultgen P.L."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/author | "Milgram S.L."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/author | "Milgram S.L."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/author | "Ostrowski L.E."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/author | "Ostrowski L.E."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/pages | "4156-4166"xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/pages | "4156-4166"xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/title | "Characterization of an A-kinase anchoring protein in human ciliary axonemes."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/title | "Characterization of an A-kinase anchoring protein in human ciliary axonemes."xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/12475942 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12475942 |
| http://purl.uniprot.org/citations/12475942 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12475942 |