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| http://purl.uniprot.org/citations/12475993 | http://www.w3.org/2000/01/rdf-schema#comment | "Mcl-1L (myeloid cell leukemia-1 long) is an antiapoptotic Bcl-2 family protein discovered as an early induction gene during leukemia cell differentiation. Previously, we identified Mcl-1S (short) as a short splicing variant of the Mcl-1 gene with proapoptotic activity. To identify Mcl-1-interacting proteins, we performed yeast two-hybrid screening and found cDNAs encoding tankyrase 1. This protein possesses poly(ADP-ribose) polymerase activity and presumably facilitates the turnover of substrates following ADP-ribosylation. In yeast and mammalian cells, tankyrase 1 interacts with both Mcl-1L and Mcl-1S, but does not bind to other Bcl-2 family proteins tested. Analysis of truncated tankyrase 1 mutants indicated that the first 10 ankyrin repeats are involved in interaction with Mcl-1. In the N terminus of Mcl-1, a stretch of 25 amino acids is sufficient for binding to tankyrase 1. Overexpression of tankyrase 1 antagonizes both Mcl-1L-mediated cell survival and Mcl-1S-induced cell death. Furthermore, coexpression of tankyrase 1 with Mcl-1L or Mcl-1S decreased the levels of Mcl-1 proteins. Although tankyrase 1 down-regulates Mcl-1 protein expression, no ADP-ribosylation of Mcl-1 was detected. In contrast, overexpression of Mcl-1 proteins suppressed the ADP-ribosylation of the telomeric repeat binding factor 1, another tankyrase 1-interacting protein. Thus, interaction of Mcl-1L and Mcl-1S with tankyrase 1 could serve as a unique mechanism to decrease the expression of these Bcl-2 family proteins, thereby leading to the modulation of the apoptosis pathway."xsd:string |
| http://purl.uniprot.org/citations/12475993 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m201988200"xsd:string |
| http://purl.uniprot.org/citations/12475993 | http://purl.uniprot.org/core/author | "Donigian J.R."xsd:string |
| http://purl.uniprot.org/citations/12475993 | http://purl.uniprot.org/core/author | "Bae J."xsd:string |
| http://purl.uniprot.org/citations/12475993 | http://purl.uniprot.org/core/author | "Hsueh A.J."xsd:string |
| http://purl.uniprot.org/citations/12475993 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12475993 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12475993 | http://purl.uniprot.org/core/pages | "5195-5204"xsd:string |
| http://purl.uniprot.org/citations/12475993 | http://purl.uniprot.org/core/title | "Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12475993 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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