Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/12477229http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12477229http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To evaluate the relationship between the presence of different HLA-DRB1 genes and predisposition to develop a sporadic form of ankylosing spondylitis (AS) in a demographically well-defined population.

Methods

One hundred fifteen selected patients with sporadic (non-familial) forms of AS from six different cities and 748 bone marrow donors as control group. All individuals were typed for HLA-B27 by flow cytometry with monoclonal antibodies and PCR -SSP, as well as for HLA-DRB using the Dynal ELI SSO HLA-DRB Test (Dynal AS, Oslo, Norway). The Inno-Lipa DRB Decoder (Innogenetics NV Zwijndrecht, Belgium), was used for high-resolution HLA-DRB typing.

Results

The presence of the DRB1*01 antigen in the studied population is significantiy higher in B27 positive healthy individuals (bone marrow donors) than in B27 positive AS patients; also, DRB1*01 is higher in B27 negative AS patients than 827 negative controls. The frequency of DRB1*03 is higher in B27 negative controls than B27 negative AS patients.

Conclusion

The results of this study suggest that DRB1*01 antigens might be involved in the development of sporadic forms of ankylosing spondylitis in HLA-B27 negative individuals in the studied area."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.org/dc/terms/identifier"doi:10.1016/s1297-319x(02)00430-x"xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Gonzalez R."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Munoz E."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Sanchez M."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Pena J."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Escudero A."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Collantes-Estevez E."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Munoz-Villanueva M.C."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Perez-Guijo V."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/author"Veroz R."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/name"Joint Bone Spine"xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/pages"458-462"xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/title"Distribution of HLA-DRB1 genes in patients with sporadic ankylosing spondylitis in the south of Spain."xsd:string
http://purl.uniprot.org/citations/12477229http://purl.uniprot.org/core/volume"69"xsd:string
http://purl.uniprot.org/citations/12477229http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12477229
http://purl.uniprot.org/citations/12477229http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12477229
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-12477229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12477229
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-12477229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12477229
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-12477229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12477229
http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-12477229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12477229
http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-12477229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12477229
http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-12477229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12477229
▶