| http://purl.uniprot.org/citations/12482610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12482610 | http://www.w3.org/2000/01/rdf-schema#comment | "Using antibody against the Rho binding domain of ROKalpha, two neuronal phosphoproteins of 62 and 80 kDa were co-immunoprecipitated from brain extracts. Peptide analysis revealed their identity as collapsin response mediator proteins (CRMPs); p62 was CRMP-2 whereas p80 was a novel splice form of CRMP-1 with an extended N-terminus. p80 CRMP-1 was able to complex with CRMP-2, suggesting that p80 CRMP-1 and CRMP-2 form oligomers. CRMP-2 was the major substrate of ROK. p80 CRMP-1 interacted with the kinase domain of ROKalpha, resulting in inhibition of the catalytic activity towards other substrates. Over-expression of p80 CRMP-1 and CRMP-2 together counteracted the effects of RhoA on neurite retraction, an effect enhanced by mutation of the ROK phosphorylation site in CRMP-2. p80 CRMP-1 and CRMP-2 may be modulators of RhoA-dependent signaling, through interaction with and regulation of ROKalpha."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(02)03736-5"xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/author | "Lim L."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/author | "Hall C."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/author | "Leung T."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/author | "Tan I."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/author | "Cheong A."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/author | "Ng C.H."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/author | "Ng Y."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/pages | "445-449"xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/title | "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology."xsd:string |
| http://purl.uniprot.org/citations/12482610 | http://purl.uniprot.org/core/volume | "532"xsd:string |
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