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| http://purl.uniprot.org/citations/12486144 | http://www.w3.org/2000/01/rdf-schema#comment | "Serotonin 2C (5-HT2C) receptor pre-mRNA is a substrate for RNA editing enzymes that convert five adenosines (named A, B, C', C, and D editing sites) to inosines. Editing of two of these sites (C' and C) is crucial for decreasing the efficiency of the receptor to activate G-protein. Nucleotide sequence analysis of mouse forebrain neocortical 5-HT2C mRNA isoforms revealed that editing at these two sites is regulated in a serotonin-dependent manner. In serotonin-depleted mice, C'- and C-site editing is significantly decreased. This results in an increased expression of 5-HT2C mRNA isoforms encoding receptors with higher sensitivity to serotonin. In contrast, a 4 d treatment with the 5-HT2A/2C agonist (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane significantly increases the editing frequency at the C' site and leads to increased expression of 5-HT2C mRNA isoforms encoding receptors that activate G-protein least efficiently. None of the drug treatments led to alterations in cytoplasmic 5-HT2C mRNA levels. These data indicate that editing of 5-HT2C pre-mRNA is a mechanism that retains basic response properties of 5-HT2C receptors in the face of changing synaptic input to keep receptor activation within an optimal range for information processing. Key words: serotonin; 5."xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.22-24-10529.2002"xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/author | "Englander M.T."xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/author | "Gurevich I."xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/author | "Schmauss C."xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/author | "Adlersberg M."xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/author | "Siegal N.B."xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/pages | "10529-10532"xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/title | "Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission."xsd:string |
| http://purl.uniprot.org/citations/12486144 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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