| http://purl.uniprot.org/citations/12486241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12486241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12486241 | http://www.w3.org/2000/01/rdf-schema#comment | "Circulating human natural killer (NK) lymphocytes have been functionally defined by their ability to exert cytotoxic activity against MHC class I-negative target cell lines, including K562. Therefore, it was proposed that NK cells recognized the "missing self." We show here that the Ig-like CD160 receptor expressed by circulating CD56(dim+) NK cells or IL-2-deprived NK cell lines is mainly involved in their cytotoxic activity against K562 target cells. Further, we report that HLA-C molecules that are constitutively expressed by K562 trigger NK cell lysis through CD160 receptor engagement. In addition, we demonstrate, with recombinant soluble HLA-Cw3 and CD160 proteins, direct interaction of these molecules. We also find that CD158b inhibitory receptors partially interfere with CD160-mediated cytotoxicity, whereas CD94CD159a and CD85j have no effect on engagement with their respective ligands. Thus, CD160HLA-C interaction constitutes a unique pathway to trigger NK cell cytotoxic activity."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.012681099"xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.012681099"xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Lenfant F."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Lenfant F."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Aguerre-Girr M."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Aguerre-Girr M."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Barakonyi A."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Barakonyi A."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Bensussan A."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Bensussan A."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Boumsell L."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Boumsell L."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Giustiniani J."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Giustiniani J."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Hilgert I."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Hilgert I."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Le Bouteiller P."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Le Bouteiller P."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Mami-Chouaib F."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Mami-Chouaib F."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |
| http://purl.uniprot.org/citations/12486241 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |