| http://purl.uniprot.org/citations/12488451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12488451 | http://www.w3.org/2000/01/rdf-schema#comment | "The class A scavenger receptor (SR-A) binds modified lipoproteins and has been implicated in cholesterol ester deposition in macrophages. The SR-A also contributes to cellular adhesion. Using SR-A(+/+) and SR-A(-)/-murine macrophages, we found SR-A expression important for both divalent cation-dependent and -independent adhesion of macrophages to the human smooth muscle cell extracellular matrix. The SR-A mediated 65 and 85% of macrophage adhesion to the extracellular matrix in the presence and absence of serum, respectively. When EDTA was added to chelate divalent cations, the SR-A mediated 90 and 95% of the macrophage adhesion without and with serum, respectively. SR-A-mediated adhesion to the extracellular matrix was prevented by fucoidin, an SR-A antagonist. Biglycan and decorin, proteoglycans of the extracellular matrix, were identified as SR-A ligands. Compared with control cells, Chinese hamster ovary cells expressing the SR-A showed 5- and 6-fold greater cell association (binding and internalization) of (125)I-decorin and -biglycan, respectively. In competition studies, unlabeled proteoglycan or fucoidin competed for binding of (125)I-labeled decorin and -biglycan, and biglycan and decorin competed for the SR-A-mediated cell association and degradation of (125)I-labeled acetylated LDL, a well characterized ligand for the SR-A. These results suggest that the SR-A could contribute to the adhesion of macrophages to the extracellular matrix of atherosclerotic plaques."xsd:string |
| http://purl.uniprot.org/citations/12488451 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m208358200"xsd:string |
| http://purl.uniprot.org/citations/12488451 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/12488451 | http://purl.uniprot.org/core/author | "Pitas R.E."xsd:string |
| http://purl.uniprot.org/citations/12488451 | http://purl.uniprot.org/core/author | "Santiago-Garcia J."xsd:string |
| http://purl.uniprot.org/citations/12488451 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12488451 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12488451 | http://purl.uniprot.org/core/pages | "6942-6946"xsd:string |
| http://purl.uniprot.org/citations/12488451 | http://purl.uniprot.org/core/title | "The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix."xsd:string |
| http://purl.uniprot.org/citations/12488451 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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