| http://purl.uniprot.org/citations/12496166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12496166 | http://www.w3.org/2000/01/rdf-schema#comment | "4-1BB (CD137) is induced on activated CD4(+) and CD8(+) T cells and delivers a costimulatory signal upon binding the 4-1BB ligand (4-1BBL) expressed on antigen-presenting cells. Induction of 4-1BB is dependent on activation via the T-cell receptor (TCR) and possibly CD28. It was previously demonstrated that both an in vivo protein (pneumococcal surface protein A [PspA])- and polysaccharide (phosphorylcholine [PC] determinant of teichoic acid)-specific immunoglobulin (Ig) isotype response to Streptococcus pneumoniae was dependent on CD4(+) TCRalphabeta(+) T cells and B7-dependent costimulation through CD28. We thus postulated that 4-1BB costimulation would also play a role in regulating the in vivo anti-PspA and anti-PC response to S. pneumoniae. We demonstrate that mice genetically deficient in 4-1BBL elicit a markedly reduced IgM and IgG anti-PC but normal primary and secondary IgG anti-PspA responses to S. pneumoniae relative to those for wild-type mice. However, injection of an agonistic anti-4-1BB monoclonal antibody (MAb), while having no significant effect on the anti-PC response, strongly inhibits the primary anti-PspA response, the generation of PspA-specific memory, and germinal center formation but does not induce a lasting state of tolerance. In contrast, anti-4-1BB MAb has no effect on the anti-PspA response when injected only at the time of secondary immunization. Delay of the addition of anti-4-1BB leads to progressively less inhibition of the primary response up to day 8. This inhibition is independent of CD8(+) T cells and is associated with the expansion of CD4(+) T cells with an activated phenotype, which is partly dependent on B7-dependent costimulation. These data are the first to suggest a stimulatory role for endogenous 4-1BB-4-1BBL interactions during a humoral immune response to a pathogen and further underscore significant differences in costimulation requirements for an in vivo protein-versus polysaccharide-specific Ig isotype response to an extracellular bacterium."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.71.1.196-204.2003"xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/author | "Dawicki W."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/author | "Watts T.H."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/author | "Wu Z.Q."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/author | "Khan A.Q."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/author | "Snapper C.M."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/author | "Mittler R.S."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/author | "Wolcott K.M."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/pages | "196-204"xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/title | "4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae."xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/12496166 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12496166 |
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