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| http://purl.uniprot.org/citations/12496428 | http://www.w3.org/2000/01/rdf-schema#comment | "Mcl-1 protein expression was found to be up-regulated during infection with virulent Mycobacterium tuberculosis strain H37Rv. Mcl-1 induction in THP-1 cells was optimal at a multiplicity of infection of 0.8-1.2 bacilli per macrophage and was independent of opsonin coating of the bacteria. Mcl-1 expression was elevated as early as 4 h, peaked at 5.8-fold above control cells at 24 h, and remained elevated at 48 h after infection. In THP-1 cells, mMcl-1 mRNA was induced by infection with live H37Rv but not with attenuated M. tuberculosis strain H37Ra, heat-killed H37Rv, or latex beads. In THP-1 cells and monocyte-derived macrophages (MDMs), Mcl-1 protein was induced by infection with live H37Rv but not with attenuated M. tuberculosis strain H37Ra, heat-killed H37Rv, or latex beads. Treatment of uninfected, H37Ra-infected, and H37Rv-infected THP-1 cells and MDMs with antisense oligonucleotides to mcl-1 reduced Mcl-1 expression by >84%. This resulted in an increase in apoptosis of both MDMs and THP-1 cells that were infected with H37Rv, but not cells that were uninfected or infected with H37Ra. Increased apoptosis correlated with a decrease in M. tuberculosis CFUs recovered from antisense-treated, H37Rv-infected cells at 4 and 7 days after infection. In contrast, CFU recoveries from sense-treated, H37Rv-infected cells or from antisense- or sense-treated, H37Ra-infected cells were unchanged from controls. Thus, the antiapoptotic effect of the induction of Mcl-1 expression in H37Rv-infected macrophages promotes the survival of virulent M. tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.170.1.430"xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/author | "McMaster W.R."xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/author | "Reiner N.E."xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/author | "Hingley-Wilson S.M."xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/author | "Sly L.M."xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/pages | "430-437"xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/title | "Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1."xsd:string |
| http://purl.uniprot.org/citations/12496428 | http://purl.uniprot.org/core/volume | "170"xsd:string |
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