| http://purl.uniprot.org/citations/12498690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12498690 | http://www.w3.org/2000/01/rdf-schema#comment | "Control of ribosome biogenesis is a potential mechanism for the regulation of cell size during growth, and a key step in regulating ribosome production is ribosomal RNA synthesis by RNA polymerase I (Pol I). In humans, Pol I transcription requires the upstream binding factor UBF and the selectivity factor SL1 to assemble coordinately on the promoter. UBF is an HMG box-containing factor that binds to the rDNA promoter and activates Pol I transcription through its acidic carboxy-terminal tail. Using UBF (284-670) as bait in a yeast two-hybrid screen, we have identified an interaction between UBF and TAF1, a factor involved in the transcription of cell cycle and growth regulatory genes. Coimmunoprecipitation and protein-protein interaction assays confirmed that TAF1 binds to UBF. Confocal microscopy showed that TAF1 colocalizes with UBF in Hela cells, and cell fractionation experiments provided further evidence that a portion of TAF1 is localized in the nucleolus, the organelle devoted to ribosomal DNA transcription. Cotransfection and in vitro transcription assays showed that TAF1 stimulates Pol I transcription in a dosage-dependent manner. Thus, TAF1 may be involved in the coordinate expression of Pol I- and Pol II-transcribed genes required for protein biosynthesis and cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(02)01389-1"xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/author | "Lin C.Y."xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/author | "Comai L."xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/author | "Tuan J."xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/author | "Scalia P."xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/author | "Bui T."xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/pages | "2142-2146"xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/title | "The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF."xsd:string |
| http://purl.uniprot.org/citations/12498690 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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