| http://purl.uniprot.org/citations/12502730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12502730 | http://www.w3.org/2000/01/rdf-schema#comment | "Although CD4(+) T cells form a major subset of TCRalphabeta T cells, only a small number of TCRgammadelta T cells express CD4. Factors contributing to the down-regulation of CD4(+) TCRgammadelta T cells have not been identified. The CD5 molecule is expressed on most TCRgammadelta T cells in the spleen, whereas only a few intestinal intraepithelial TCRgammadelta T cells express this molecule in wild-type mice and TCRbeta mutant (beta(-/-)) mice. Unexpectedly, in the present studies, the lack of CD5 led to a remarkable increase of a CD4(+) TCRgammadelta T cell subset in CD5(-/-)beta(-/-) mice. The CD4(+) TCRgammadelta T cells were also detectable in MHC II(-/-)CD5(-/-)beta(-/-) triple-mutant mice. This CD4(+) TCRgammadelta T cell subset provided help in Mycobacterium-induced germinal center (GC) formation and showed a T(h)-like cytokine profile. In contrast, CD5(+) TCRgammadelta T cells suppressed the CD4(+) TCRgammadelta T cell-mediated GC formation, presumably by eliminating this CD4(+) subset. Unlike intraepithelial gammadelta T cells, >30% of TCRgammadelta T cells in the colonic lamina propria (LP) expressed CD5. The lack of CD5 also led to increased numbers of CD4(+) TCRgammadelta T cells in the colonic LP and increased susceptibility to development of chronic colitis in beta(-/-) mice. Cell transfer studies suggest that CD5(+) TCRgammadelta T cells are capable of selectively eliminating CD4(+) TCRgammadelta T cells in the intestine. The CD4(+) TCRgammadelta T cells possess immune functions similar to CD4(+) TCRalphabeta T cells."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxg006"xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/author | "Bhan A.K."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/author | "Mizoguchi A."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/author | "Preffer F.I."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/author | "Takedatsu H."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/author | "de Jong Y.P."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/author | "Mizoguchi E."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/pages | "97-108"xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/title | "Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation."xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/12502730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12502730 |
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