| http://purl.uniprot.org/citations/12504025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12504025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12504025 | http://www.w3.org/2000/01/rdf-schema#comment | "Cullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes. Covalent modification of cullins by the ubiquitin-like protein NEDD8 activates cullin ligases through an as yet undefined mechanism. We show here that p120(CAND1) selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation. CAND1 formed a ternary complex with CUL1 and ROC1. CAND1 dissociated SKP1 from CUL1 and inhibited SCF ligase activity in vitro. Suppression of CAND1 in vivo increased the level of the CUL1-SKP1 complex. We suggest that by restricting SKP1-CUL1 interaction, CAND1 regulated the assembly of productive SCF ubiquitin ligases, allowing a common CUL1-ROC core to be utilized by a large number of SKP1-F box-substrate subcomplexes."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00783-9"xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(02)00783-9"xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/author | "Furukawa M."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/author | "Furukawa M."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/pages | "1511-1518"xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/pages | "1511-1518"xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/title | "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/title | "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases."xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12504025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12504025 |
| http://purl.uniprot.org/citations/12504025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12504025 |