| http://purl.uniprot.org/citations/12504082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12504082 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 21 (IL-21) is a recently identified novel cytokine that plays an important role in the regulation of B, T, and NK cell functions. Its effects depend on binding to and signaling through an IL-21 receptor complex consisting of the IL-21 receptor (IL-21R) and the common gamma-chain (gamma(c)). In this study using biosensor technique, the ligand-binding properties of IL-21R and gamma(c), which are presently poorly understood on a molecular level, were analyzed employing recombinant ectodomains of IL-21R and gamma(c). The formation of a binary complex between IL-21 and immobilized IL-21R (K(D) 70pM), gamma(c) and immobilized IL-21 (K(D) 160 microM) and a ternary complex between gamma(c) and IL-21 saturated immobilized IL-21R (K(D) 160nM) could be analyzed. The gamma(c) residues involved in IL-21 binding were defined by alanine-scanning mutational analysis. The epitope comprises gamma(c) residues N44, Y103, N128, L161, E162, and L208. It is not identical but partially overlapping with the previously established gamma(c) epitope for IL-4 binding. These results open the way to understand the molecular recognition mechanism in the IL-21 receptor system and also the promiscuous binding properties of gamma(c)."xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02836-x"xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://purl.uniprot.org/core/author | "Sebald W."xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://purl.uniprot.org/core/author | "Zhang J.L."xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://purl.uniprot.org/core/author | "Foster D."xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12504082 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://purl.uniprot.org/core/pages | "291-296"xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://purl.uniprot.org/core/title | "Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain."xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://purl.uniprot.org/core/volume | "300"xsd:string |
| http://purl.uniprot.org/citations/12504082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12504082 |
| http://purl.uniprot.org/citations/12504082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12504082 |
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| http://purl.uniprot.org/uniprot/#_Q5FC01-mappedCitation-12504082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12504082 |