| http://purl.uniprot.org/citations/12506198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12506198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12506198 | http://www.w3.org/2000/01/rdf-schema#comment | "Disrupted-in-Schizophrenia-1 (DISC-1) is a gene whose mutant truncation is associated with major psychiatric illness with a predominance of schizophrenic symptomatology. We have cloned and characterized rodent DISC-1. DISC-1 expression displays pronounced developmental regulation with the highest levels in late embryonic life when the cerebral cortex develops. In yeast two-hybrid analyses, DISC-1 interacts with a variety of cytoskeletal proteins. One of these, NudE-like (NUDEL), is associated with cortical development and is linked to LIS-1, the disease gene for a form of lissencephaly, a disorder of cortical development. The disease mutant form of DISC-1 fails to bind NUDEL. Expression of mutant, but not wild-type, DISC-1 in PC12 cells reduces neurite extension. As schizophrenia is thought to reflect defects in cortical development that are determined by cytoskeletal protein activities, the cellular disturbances we observe with mutant DISC-1 may be relevant to psychopathologic mechanisms."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0136913100"xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0136913100"xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Kamiya A."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Kamiya A."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Ozeki Y."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Ozeki Y."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Ross C.A."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Ross C.A."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Yamada N."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Yamada N."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Snyder S.H."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Snyder S.H."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Fujii K."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Fujii K."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Hatten M.E."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Hatten M.E."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Tomoda T."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Tomoda T."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Sawa A."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Sawa A."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Okawa M."xsd:string |
| http://purl.uniprot.org/citations/12506198 | http://purl.uniprot.org/core/author | "Okawa M."xsd:string |