| http://purl.uniprot.org/citations/12507774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12507774 | http://www.w3.org/2000/01/rdf-schema#comment | "Opiates are major analgesics and addictive drugs described also as immunomodulators. Here, we investigated the contribution of kappa-opioid receptor (KOR) activity in immunity in vivo by studying immune responses in KOR knockout mice. These animals displayed a modest reduction in thymus cellularity and CD4(+) cell ratio, parallel to a slight increase in immature CD4(+)CD8(+) lymphocytes. In spleen, KOR null animals showed augmented cell number with no change in cell distribution. T and B lymphocyte proliferative capabilities in vitro, Natural Killer activity and steady-state Ig levels were unchanged in KOR-/-mice. We immunized the mice with the antigen keyhole limpet hemocyanin (KLH). Compared to wild-type (WT) mice, KOR-/-animals produced significant higher levels of antigen-specific total Ig, IgM, IgG1 and IgG2a antibodies. This enhancement of humoral activity was not observed in mu-opioid receptor and delta-opioid receptor knockout animals. These results show that endogenous activation of kappa-opioid receptors may exert a tonic inhibition of antibody (Ab) response."xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0165-5728(02)00419-8"xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/author | "Kieffer B.L."xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/author | "Simonin F."xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/author | "Gaveriaux-Ruff C."xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/author | "Filliol D."xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/name | "J Neuroimmunol"xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/pages | "72-81"xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/title | "Enhanced humoral response in kappa-opioid receptor knockout mice."xsd:string |
| http://purl.uniprot.org/citations/12507774 | http://purl.uniprot.org/core/volume | "134"xsd:string |
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