| http://purl.uniprot.org/citations/12508316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12508316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12508316 | http://www.w3.org/2000/01/rdf-schema#comment | "Melanopsin is a newly discovered photopigment that is believed to be involved in the regulation of circadian rhythms in tetrapods. Here we describe the characterization of the first two teleost melanopsins (opn4a and opn4b) isolated from Atlantic cod (Gadus morhua). These two teleost genes belong to a subgroup of melanopsins that also include members from Xenopus, chicken, and Takifugu. In situ hybridization revealed that opn4a and opn4b are differentially expressed within the retina and brain. In the larval and adult retina, both melanopsins are expressed in a subset of cells in the inner retina, resembling amacrine and ganglion cells. In addition, opn4a is expressed in the horizontal cells, indicating a separate task for this gene. In the brain, the two melanopsins are separately expressed in two major retinal and extraretinal photosensitive integration centers, namely, the suprachiasmatic nucleus (opn4a) and the habenula (opn4b). The expression of opn4a in the suprachiasmatic nucleus in cod is similar to the melanopsin expression found in Xenopus. This suggests a conserved role for this opsin and an involvement in mediation of nonvisual photoreceptive tasks, such as entraining circadian rhythms and/or hypophysiotrophic systems. The differential expression of opn4b in the habenula suggests that this gene plays a role similar to that of opn4a, in that it is also situated in an area that integrates photic inputs from the pineal as well as other brain regions. Thus, the habenula may be an additional region that mediates photic cues in teleosts."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.10523"xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.10523"xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Fjose A."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Fjose A."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Seo H.C."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Seo H.C."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Drivenes O."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Drivenes O."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Ebbesson L.O."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Ebbesson L.O."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Helvik J.V."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Helvik J.V."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Soviknes A.M."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/author | "Soviknes A.M."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/name | "J. Comp. Neurol."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/name | "J. Comp. Neurol."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/pages | "84-93"xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/pages | "84-93"xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/title | "Isolation and characterization of two teleost melanopsin genes and their differential expression within the inner retina and brain."xsd:string |
| http://purl.uniprot.org/citations/12508316 | http://purl.uniprot.org/core/title | "Isolation and characterization of two teleost melanopsin genes and their differential expression within the inner retina and brain."xsd:string |