| http://purl.uniprot.org/citations/12509254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12509254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12509254 | http://www.w3.org/2000/01/rdf-schema#comment | "Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double-strand breaks (DSBs) in mammalian cells. DNA-dependent protein kinase (DNA-PK), ligase IV, and XRCC4 are all critical components of the NHEJ repair pathway. DNA-PK is composed of a heterodimeric DNA-binding component, Ku, and a large catalytic subunit, DNA-PKcs. Ligase IV and XRCC4 associate to form a multimeric complex that is also essential for NHEJ. DNA-PK and ligase IV/XRCC4 interact at DNA termini which results in stimulated ligase activity. Here, we define interactions between the components of these two essential complexes, DNA-PK and ligase IV/XRCC4. We find that ligase IV/XRCC4 associates with DNA-PK in a DNA-independent manner. The specific protein-protein interactions that mediate the interaction between these two complexes are further identified. Direct interactions between ligase IV and Ku as well as between XRCC4 and DNA-PKcs are shown. In contrast, binding of ligase IV to DNA-PKcs or XRCC4 to Ku is very weak or non-existent. Our data defines the specific protein pairs involved in the association of DNA-PK and ligase IV/XRCC4, and suggests a molecular mechanism for coordinating the assembly of the DNA repair complex at DNA breaks."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1568-7864(01)00018-0"xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1568-7864(01)00018-0"xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/author | "Yannone S.M."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/author | "Yannone S.M."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/author | "Hsu H.-L."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/author | "Hsu H.-L."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/name | "DNA Repair"xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/name | "DNA Repair"xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/pages | "225-235"xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/pages | "225-235"xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/title | "Defining interactions between DNA-PK and ligase IV/XRCC4."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/title | "Defining interactions between DNA-PK and ligase IV/XRCC4."xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/12509254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12509254 |
| http://purl.uniprot.org/citations/12509254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12509254 |
| http://purl.uniprot.org/citations/12509254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12509254 |
| http://purl.uniprot.org/citations/12509254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12509254 |