| http://purl.uniprot.org/citations/12509430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12509430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12509430 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation of heterotrimeric G proteins is accomplished primarily by the guanine nucleotide exchange activity of ligand-bound G protein-coupled receptors. The existence of nonreceptor guanine nucleotide exchange factors for G proteins has also been postulated. Yeast two-hybrid screens with Galpha(o) and Galpha(s) as baits were performed to identify binding partners of these proteins. Two mammalian homologs of the Caenorhabditis elegans protein Ric-8 were identified in these screens: Ric-8A (Ric-8/synembryn) and Ric-8B. Purification and biochemical characterization of recombinant Ric-8A revealed that it is a potent guanine nucleotide exchange factor for a subset of Galpha proteins including Galpha(q), Galpha(i1), and Galpha(o), but not Galpha(s). The mechanism of Ric-8A-mediated guanine nucleotide exchange was elucidated. Ric-8A interacts with GDP-bound Galpha proteins, stimulates release of GDP, and forms a stable nucleotide-free transition state complex with the Galpha protein; this complex dissociates upon binding of GTP to Galpha."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m211862200"xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m211862200"xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/author | "Gilman A.G."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/author | "Gilman A.G."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/author | "Tall G.G."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/author | "Tall G.G."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/author | "Krumins A.M."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/author | "Krumins A.M."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/pages | "8356-8362"xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/pages | "8356-8362"xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/title | "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/title | "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor."xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12509430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12509430 |
| http://purl.uniprot.org/citations/12509430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12509430 |
| http://purl.uniprot.org/citations/12509430 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12509430 |
| http://purl.uniprot.org/citations/12509430 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12509430 |