| http://purl.uniprot.org/citations/12511654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/12511654 | http://www.w3.org/2000/01/rdf-schema#comment | "How scaffold proteins control information flow in signaling pathways is poorly understood: Do they simply tether components, or do they precisely orient and activate them? We found that the yeast mitogen-activated protein (MAP) kinase scaffold Ste5 is tolerant to major stereochemical perturbations; heterologous protein interactions could functionally replace native kinase recruitment interactions, indicating that simple tethering is largely sufficient for scaffold-mediated signaling. Moreover, by engineering a scaffold that tethers a unique kinase set, we could create a synthetic MAP kinase pathway with non-natural input-output properties. These findings demonstrate that scaffolds are highly flexible organizing factors that can facilitate pathway evolution and engineering."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1076979"xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1076979"xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/author | "Lim W.A."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/author | "Lim W.A."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/author | "Zarrinpar A."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/author | "Zarrinpar A."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/pages | "1061-1064"xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/pages | "1061-1064"xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/title | "Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/title | "Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms."xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/volume | "299"xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://purl.uniprot.org/core/volume | "299"xsd:string |
| http://purl.uniprot.org/citations/12511654 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12511654 |
| http://purl.uniprot.org/citations/12511654 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12511654 |
| http://purl.uniprot.org/citations/12511654 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12511654 |
| http://purl.uniprot.org/citations/12511654 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12511654 |