| http://purl.uniprot.org/citations/12514131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12514131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12514131 | http://www.w3.org/2000/01/rdf-schema#comment | "We report that the multidomain protein POSH (plenty of SH3s) acts as a scaffold for the JNK pathway of neuronal death. This pathway consists of a sequential cascade involving activated Rac1/Cdc42, mixed-lineage kinases (MLKs), MAP kinase kinases (MKKs) 4 and 7, c-Jun N-terminal kinases (JNKs) and c-Jun, and is required for neuronal death induced by various means including nerve growth factor (NGF) deprivation. In addition to binding GTP-Rac1 as described previously, we find that POSH binds MLKs both in vivo and in vitro, and complexes with MKKs 4 and 7 and with JNKs. POSH overexpression promotes apoptotic neuronal death and this is suppressed by dominant-negative forms of MLKs, MKK4/7 and c-Jun, and by an MLK inhibitor. Moreover, a POSH antisense oligonucleotide and a POSH small interfering RNA (siRNA) suppress c-Jun phosphorylation and neuronal apoptosis induced by NGF withdrawal. Thus, POSH appears to function as a scaffold in a multiprotein complex that links activated Rac1 and downstream elements of the JNK apoptotic cascade."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg021"xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg021"xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/author | "Greene L.A."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/author | "Greene L.A."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/author | "Kukekov N.V."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/author | "Kukekov N.V."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/pages | "252-261"xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/pages | "252-261"xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/title | "POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/title | "POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12514131 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12514131 |
| http://purl.uniprot.org/citations/12514131 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12514131 |
| http://purl.uniprot.org/citations/12514131 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12514131 |
| http://purl.uniprot.org/citations/12514131 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12514131 |