| http://purl.uniprot.org/citations/12514734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12514734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12514734 | http://www.w3.org/2000/01/rdf-schema#comment | "The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT(-/-) mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni882"xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni882"xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Janssen E."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Janssen E."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Zhang W.'"xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Zhang W.'"xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Koonpaew S."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/author | "Koonpaew S."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/pages | "117-123"xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/pages | "117-123"xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/title | "LAB: a new membrane-associated adaptor molecule in B cell activation."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/title | "LAB: a new membrane-associated adaptor molecule in B cell activation."xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12514734 | http://purl.uniprot.org/core/volume | "4"xsd:string |