| http://purl.uniprot.org/citations/12517412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12517412 | http://www.w3.org/2000/01/rdf-schema#comment | "A lower rate of colon cancer was observed in consumers of coffee with a high content of the diterpenes Kahweol and Cafestol (K/C). In animal models, K/C have been found to protect against the mutagenic/carcinogenic effects of compounds such as 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), aflatoxin B1, and 7,12-dimethylbenz[a]anthracene. Thus far, such chemoprotection by K/C has been attributed to modifications of xenobiotic metabolism, e.g. enhanced detoxification by UDP-glucuronosyltransferase (UDPGT) and/or glutathione transferase (GST). In the present study, we investigated the potential of several coffee-related treatments (K/C [1:1], Cafestol-alone, Turkish coffee) to modify the expression level of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) which is involved in the reversal of the precarcinogenic DNA damage O(6)-alkylguanine induced by alkylating agents. The results show that, in the male F344 rat, K/C and Cafestol increase hepatic MGMT in a dose-dependent manner up to a maximum of 2.6-fold at 0.122% K/C in the feed. Turkish coffee led to enhancements of up to 16%, the more moderate increase being associated with the lower estimated K/C intake through the beverage. In the livers of the rats receiving Turkish coffee, we also found 10-30% increases in several GST-related parameters (overall GST, GST-pi, glutathione, gamma-glutamylcysteine-synthetase) and a two-fold increase in UDPGT activity. Dose-response studies with K/C revealed that MGMT increased in parallel with three of the four GST-related parameters whereas the dose-response curves of UDPGT and of GST-pi activity displayed a steeper slope. Increased expression level of MGMT may extend the antimutagenic/anticarcinogenic potential of coffee components to protection against DNA alkylating agents."xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0027-5107(02)00264-6"xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/author | "Kaina B."xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/author | "Nagel G."xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/author | "Schulte-Hermann R."xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/author | "Scharf G."xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/author | "Huber W.W."xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/author | "Prustomersky S."xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/name | "Mutat Res"xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/pages | "57-68"xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/title | "Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism."xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://purl.uniprot.org/core/volume | "522"xsd:string |
| http://purl.uniprot.org/citations/12517412 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12517412 |
| http://purl.uniprot.org/citations/12517412 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12517412 |
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