| http://purl.uniprot.org/citations/12517763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12517763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12517763 | http://www.w3.org/2000/01/rdf-schema#comment | "EphB6 is the most recently identified member of the Eph receptor tyrosine kinase family. EphB6 is primarily expressed in thymocytes and a subpopulation of T cells, suggesting that it may be involved in regulation of T lymphocyte differentiation and functions. We show here that overexpression of EphB6 in Jurkat T cells and stimulation with the EphB6 ligand, ephrin-B1, results in the selective inhibition of TCR-mediated activation of JNK but not the MAPK pathway. EphB6 appears to suppress the JNK pathway by preventing T cell receptor (TCR)-induced activation of the small GTPase Rac1, a critical event in initiating the JNK cascade. Furthermore, EphB6 blocked anti-CD3-induced secretion of IL-2 and CD25 expression in a ligand-dependent manner. Dominant negative EphB6 suppressed the inhibitory activity of the endogenous receptor and enhanced anti-CD3-induced JNK activation, CD25 expression, and IL-2 secretion, confirming the requirement for EphB6-specific signaling. Activation of the JNK pathway and the establishment of an IL-2/IL-2R autocrine loop have been shown to play a role in the negative selection of CD4(+)CD8(+) self-reacting thymocytes. In agreement, stimulation of murine thymocytes with ephrin-B1 not only blocked anti-CD3-induced CD25 up-regulation and IL-2 production, but also inhibited TCR-mediated apoptosis. Thus, EphB6 may play an important role in regulating thymocyte differentiation and modulating responses of mature T cells."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m208179200"xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m208179200"xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Roifman C.M."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Roifman C.M."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Freywald A."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Freywald A."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Grunberger T."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Grunberger T."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Rashotte C."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Rashotte C."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Sharfe N."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/author | "Sharfe N."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/pages | "10150-10156"xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/pages | "10150-10156"xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/title | "The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/title | "The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses."xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12517763 | http://purl.uniprot.org/core/volume | "278"xsd:string |