| http://purl.uniprot.org/citations/12517771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12517771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12517771 | http://www.w3.org/2000/01/rdf-schema#comment | "In the nonhomologous end joining pathway of DNA double-strand break repair, the ligation step is catalyzed by a complex of XRCC4 and DNA ligase IV. Extracts of CHO-K1 cells are able to accurately rejoin a site-specific free radical-mediated double-strand break with partially complementary overhangs, by a mechanism involving alignment-based gap filling followed by ligation. Extracts of XR-1 cells, which lack XRCC4 and DNA ligase IV, carried out neither gap filling nor ligation. Supplementation of the extracts with recombinant XRCC4/ligase IV, but not with XRCC4 alone, restored gap filling and accurate end joining. The results imply that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/author | "Lee J.W."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/author | "Lee J.W."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/author | "Yannone S.M."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/author | "Yannone S.M."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/author | "Povirk L.F."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/author | "Povirk L.F."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/pages | "22-24"xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/pages | "22-24"xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/title | "Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/title | "Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro."xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/12517771 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12517771 |
| http://purl.uniprot.org/citations/12517771 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12517771 |
| http://purl.uniprot.org/citations/12517771 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12517771 |
| http://purl.uniprot.org/citations/12517771 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12517771 |