| http://purl.uniprot.org/citations/12518233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12518233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12518233 | http://www.w3.org/2000/01/rdf-schema#comment | "The effects of Hainantoxin-IV (HNTX-IV), a neurotoxic peptide isolated from the venom of the Chinese bird spider Seleconosmia hainana, on the adult rat dorsal root ganglion (DRG) neurons were investigated. Using the whole-cell patch-clamp technique HNTX-IV inhibited mammal neural TTX-sensitive (TTX-S) sodium currents evidently but the toxin failed to affect TTX-resistant (TTX-R) ones. The inhibition of HNTX-IV is dose-dependent with the IC(50) value of 44.6 nmol/L. The toxin didn't affect the activation and inactivation kinetics of sodium currents, but it caused a 10.1 mV hyperpolarizing shift in the voltage midpoint of steady-state sodium channel inactivation on DRG neurons. The results indicated that HNTX-IV, a novel spider toxin, maybe alternate voltage-gated sodium channels through a mechanism distinct from other spider toxins such as delta-ACTXs, mu-agatoxins I-VI which targeted the receptor site 3 to slow the inactivation kinetics of sodium currents."xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/author | "Liang S.-P."xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/author | "Liang S.-P."xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/author | "Xiao Y.-C."xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/author | "Xiao Y.-C."xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/name | "Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao"xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/name | "Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao"xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/pages | "82-85"xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/pages | "82-85"xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/title | "Inhibition of sodium channels in rat dorsal root ganglion neurons by Hainantoxin-IV, a novel spider toxin."xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/title | "Inhibition of sodium channels in rat dorsal root ganglion neurons by Hainantoxin-IV, a novel spider toxin."xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/12518233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12518233 |
| http://purl.uniprot.org/citations/12518233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12518233 |
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| http://purl.uniprot.org/uniprot/D2Y232#attribution-3298E988BF5CDCF60FE8093D1DB75E69 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12518233 |