| http://purl.uniprot.org/citations/12524335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12524335 | http://www.w3.org/2000/01/rdf-schema#comment | "Yme1p, an ATP-dependent protease localized in the mitochondrial inner membrane, is required for the growth of yeast lacking an intact mitochondrial genome. Specific dominant mutations in the genes encoding the alpha- and gamma-subunits of the mitochondrial F(1)F(0)-ATPase suppress the slow-growth phenotype of yeast that simultaneously lack Yme1p and mitochondrial DNA. F(1)F(0)-ATPase activity is reduced in yeast lacking Yme1p and is restored in yme1 strains bearing suppressing mutations in F(1)-ATPase structural genes. Mitochondria isolated from yme1 yeast generated a membrane potential upon the addition of succinate, but unlike mitochondria isolated either from wild-type yeast or from yeast bearing yme1 and a suppressing mutation, were unable to generate a membrane potential upon the addition of ATP. Nuclear-encoded F(0) subunits accumulate in yme1 yeast lacking mitochondrial DNA; however, deletion of genes encoding those subunits did not suppress the requirement of yme1 yeast for intact mitochondrial DNA. In contrast, deletion of INH1, which encodes an inhibitor of the F(1)F(0)-ATPase, partially suppressed the growth defect of yme1 yeast lacking mitochondrial DNA. We conclude that Yme1p is in part responsible for assuring sufficient F(1)F(0)-ATPase activity to generate a membrane potential in mitochondria lacking mitochondrial DNA and propose that Yme1p accomplishes this by catalyzing the turnover of protein inhibitors of the F(1)F(0)-ATPase."xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/162.4.1595"xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/author | "Thorsness P.E."xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/author | "Updike D.L."xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/author | "Kominsky D.J."xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/author | "Brownson M.P."xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/pages | "1595-1604"xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/title | "Genetic and biochemical basis for viability of yeast lacking mitochondrial genomes."xsd:string |
| http://purl.uniprot.org/citations/12524335 | http://purl.uniprot.org/core/volume | "162"xsd:string |
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