| http://purl.uniprot.org/citations/12526084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12526084 | http://www.w3.org/2000/01/rdf-schema#comment | "Skeletogenesis occurs through either intramembranous or endochondral ossification. In addition, some parts of the skeletal components maintain their cartilaginous characteristics throughout life without mineralization. Runx2 is known to be a pivotal transcription factor for all skeletogenic processes. In this study, we examined the expression patterns of two major isoforms of Runx2 in early skeletogenesis. During intramembranous bone formation, Runx2-type I (Runx2-I) was widely expressed in osteoprogenitor cells and active osteoblasts, while Runx2-type II (Runx2-II) expression was stringently restricted to cells lining mineralized bones. Cells in permanent cartilage expressed collagen type II (Col-II) but never expressed Runx2 or Col-X. These permanent cartilages were well circumscribed by Runx2-I positive cells, in which Runx2-II was negative. In endochondral bone formation, Runx2 expression temporarily disappeared in Col-II-positive proliferating chondrocytes, but a secondary surge of Runx2-I expression occurred in the prehypertrophic zone before the mineralization of cartilage. Collectively, both Runx2 isoforms showed very similar expression patterns in active bone forming areas; however, Runx2-I has an exclusive role in the early commitment stage of intramembranous or endochondral bone forming processes or in cells surrounding permanent cartilage."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.org/dc/terms/identifier | "doi:10.1038/emm.2002.60"xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Park M.H."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Choi K.Y."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Bae Y.C."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Nam S."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Ryoo H.M."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/author | "Shin H.I."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/pages | "426-433"xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/title | "Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis."xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/12526084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12526084 |
| http://purl.uniprot.org/citations/12526084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12526084 |
| http://purl.uniprot.org/uniprot/#_E0CY45-mappedCitation-12526084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12526084 |
| http://purl.uniprot.org/uniprot/#_E0CZ12-mappedCitation-12526084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12526084 |
| http://purl.uniprot.org/uniprot/#_E0CZC6-mappedCitation-12526084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12526084 |
| http://purl.uniprot.org/uniprot/#_F7CN98-mappedCitation-12526084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12526084 |
| http://purl.uniprot.org/uniprot/#_F6TRA6-mappedCitation-12526084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12526084 |
| http://purl.uniprot.org/uniprot/#_F7CZB5-mappedCitation-12526084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12526084 |